Niacinamide the less bashful brother of vitamin B3(S2E10)

Vitamin B3 comes in two forms: Niacin and its amide form Niacinamide. While we have already covered Niacin in Episode 35 of season 1, Niacinamide also deserves its own episode as it has substantial benefits for health and mental wellness.

Unlike niacin, there is no skin flush when one takes Niacinamide, and it will not lower LDL cholesterol. However, like niacin, it is used for alcohol withdrawal and in the treatment of schizophrenia. It is also useful as an aid in preventing suicidal behavior (along with Lithium Orotate, Zinc Picolinate and the EPA and DHA in fish oils).


Its other crowning achievements are its abilities to lower osteoarthritis pain, prevent the development of type-1 diabetes in at-risk children, and it has a gentle sedative effect that is useful when treating a variety of emotional and neuropsychiatric illnesses.


Both Niacin and Niacinamide can cause extreme drowsiness and nausea in high doses on an empty stomach, which are reasons why we recommend it after meals that contain fat, in order to buffer its absorption. Typical doses that are used would be 300-600mg for the prevention of Type-1 diabetes, and 1500-4000mg per day in divided doses for the conditions above, based on the clinical response one has.


Tune in next episode when we’ll talk about the benefits of supplemental Chromium.

Be Well & Be Zen



R. Gaby., Vitamin B3., Nutritional Medicine (2011)., Ch. 15., pp. 69-72, ISBN13: 978-0-9828850-0-0. Fritz Perlberg Publishing, Concord, NH.

Prousky, J. (2010). Vitamin B3 for depression: Case report and review of the literature. Journal of Orthomolecular Medicine, 25(3), 137-147.

Prousky, J. (2017). Towards a Micronutrient Anti-Suicide Strategy. Journal of Orthomolecular Medicine, 32(3).

Atkins, R. (1998). Dr. Atkins Vita-Nutrient Solution: Nature’s answer to drugs., pp. 58-63. ISBN0-684-81849-3. Simon & Shuster Publishing Inc., New York.

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