Schizophrenia aka Metabolic Dysperception (S3E1)

The term Schizophrenia was coined in 1908 by Dr. Eugen Bleuler, and comes from a combination of the Latin words “skhizein” (to split), and “phren” denoting mind. However, due to the stigma that this word carries, I like to refer to the condition as “Metabolic Dysperception”. This term not only lacks stigma, but is also more indicative of the underlying biochemical imbalances that are a major reason for it’s symptoms.

Metabolic Dysperception is actually a group of brain disorders, which are characterized by errors of perception, thinking and behavior, and have what psychiatry dubs as both “positive” and “negative” symptoms. These “positive” or highly visible symptoms include delusions, paranoid thoughts and hallucinations, whereas the “negative” or less obvious ones include social withdrawal, emotional blunting and cognitive functional impairment.

Drs. Abram Hoffer, Humphrey Osmond and Carl Pfeiffer did much of the pioneering work on the biochemistry of these diseases. The Schizophrenias are a group of diseases where the above-mentioned symptoms are a result of endogenous hallucinogen production (in the forms of adrenochrome, adrenolutin and possibly dopachrome). These 3 substances are the oxidation products of adrenalin and dopamine, and tend to respond positively to high doses of vitamins B3 (Niacin or Niacinamide forms) and vitamin C, with doses of each starting at 1000mg after each meal, and up. This protocol was developed by the late Dr. Abram Hoffer and is still used presently.

Dr. Carl Pfeiffer classified this disease according to 3 main subtypes. These are Histadelia (too much histamine with low or normal blood copper levels), Histapenia (too little histamine and excess blood copper) and Kryptopyrroluria which is the excretion of the substance known as hydroxyhemopyrrolin-2-one, also called kryptopyrrole. Histadelics suffer from headaches, frequent head colds and suicidal depression, and tend to respond well to the amino acid methionine (which lowers histamine), zinc and manganese, but do not benefit as much from Vitamin B3.

Histapenics are usually paranoid, over-stimulated and have hallucinations, and respond positively to Vitamin B3, B12 injections, Folic Acid (2mg/day) and zinc. Those with Kryptopyrroluria respond to zinc (15-30mg/day), vitamin B6 (75-3000mg/day) and Manganese (10-20mg/day) as well as Vitamin B3.

What all forms of schizophrenia benefit from is a hypoallergenic diet that is low in carbohydrate. The low carb, high fat Paleolithic diet fits this criterion well. This dietary regime prevents reactive hypoglycemia (which can also make cognition worse).

Also bear in mind that these approaches require dedication on the part of the patient and their families, and will sometimes also require the use of the anti-psychotic and tranquilizing drugs, albeit in smaller doses.

Be Well and Be Zen



Gaby A R, (2011), Nutritional Medicine, Ch. 287, Schizophrenia, p. 1070-79, Fritz Perlberg Publishing, Concord, NH., ISBN 13: 978-0-9828850-0-0.

Ashok AH, Baugh J, Yeragani VK. Paul Eugen Bleuler and the origin of the term schizophrenia (SCHIZOPRENIEGRUPPE). Indian Journal of Psychiatry. 2012;54(1):95-96. doi:10.4103/0019-5545.94660.

Hoffer A, (2005), Adventures in Psychiatry, The Scientific Memoirs of Dr. Abram Hoffer, ps. 71, 101, KOS Publishing Inc., ISBN: 0-9731945-6-1.

Szatmari A, Hoffer A, Schneider R, The Effect of Adrenochrome and Niacin on the Electroencephalogram of Epileptics, Am J Psychiat., 3:606-616,1955.

Pfeiffer C, Mailloux R, Forsythe L, (1988), The Schizophrenias, Ours to Conquer, ps. 61-63, 8, 125, 134, 175, 191., Bio-Communications Press, ISBN: 0-942333-02-0.

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