Episode 29: The Intestinal Permeability Factor, aka: l-Glutamine

Self-importance seems to abound in our society these days, but, if Glutamine were a politician, it would be the quiet, very capable one as opposed to the bombastic, larger than life one. In addition to maintaining small intestinal structure and function, it aids in post surgical recovery, immune system strength, liver disease recovery, addictions, obesity, mental instability, burn healing, mitigation of chemotherapeutic toxicity and post exercise recovery.

The immunostimulatory effects of Glutamine are most likely due to its up-regulating effects on T-cells, which make it unsuitable as a therapy for chronic conditions like Crohn’s disease and ulcerative colitis, although it treats acute bouts of diarrhea well. The concentration of glutamine in skeletal muscle is 30 times higher than it is in serum, which accounts for its ability to aid in combatting fatigue.

That brings us to the intervention. For post exercise recovery, 5grams of Glutamine in water will help, in addition to stimulating lean muscle mass to increase. For immune system stimulation to aid in recovery from viral infections, 5 to 20g per day is required. For addictions control, 2 to 3g is sufficient to eliminate cravings. For severe burns, post surgery and in conjunction with chemotherapy, doses of between 20-40g daily are typically used by physicians.

Join us next week where we’ll talk about Constipation.


Be Well and Be Zen



  1. Gaby., L-Glutamine., Nutritional Medicine (2011)., ps.184-86., Ch. 42., ISBN13: 978-0-9828850-0-0. Fritz Perlberg Publishing, Concord, NH.
  2. Vahdat L., Papadopoulos K., Lange D., et al. (2001)., Reduction of paclitaxel-induced peripheral neuropathy with glutamine., Clin Cancer Res: 2001;7:1192-1197.

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